Mouse Anti-SNCA Recombinant Antibody (TAB-0750CLV)

Customer Review

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James White
05.Nov,23

Excellent for SNCA Studies

The Anti-SNCA Recombinant Antibody has been excellent for our alpha-synuclein studies. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.

Laura Harris
30.Aug,22

Effective in Immunoassays

We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for SNCA is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.

David Clark
23.Jul,21

Consistent High-Quality Results

This antibody has proven to be consistent and high-quality in our assays. The reproducible results and strong affinity for SNCA have significantly improved our experiments, making it a crucial part of our research toolkit. The consistent performance has greatly enhanced our data quality.

Q&As

1. Is the anti-SNCA recombinant antibody suitable for use in Western blotting?

   A: Yes, the anti-SNCA recombinant antibody (TAB-0750CLV) is suitable for use in Western blotting. It provides specific binding to SNCA, allowing for reliable detection in Western blot assays.

2. What is the optimal dilution for using the anti-SNCA recombinant antibody in immunofluorescence?

   A: The optimal dilution for using the anti-SNCA recombinant antibody (TAB-0750CLV) in immunofluorescence is typically 1:100 to 1:500. It is advisable to perform a dilution series to determine the best working concentration for your specific experimental conditions.

3. Can the anti-SNCA recombinant antibody be used in flow cytometry analysis?

   A: Yes, the anti-SNCA recombinant antibody (TAB-0750CLV) can be used in flow cytometry analysis. It is specifically designed to bind to SNCA, making it suitable for detecting SNCA-expressing cells in flow cytometry.

4. Is the anti-SNCA recombinant antibody effective in immunohistochemistry on paraffin-embedded tissue sections?

   A: Yes, the anti-SNCA recombinant antibody (TAB-0750CLV) is effective in immunohistochemistry on paraffin-embedded tissue sections. It provides specific binding to SNCA, allowing for detailed analysis of its expression in tissue samples.

5. What are the storage recommendations for the anti-SNCA recombinant antibody?

   A: The recommended storage condition for the anti-SNCA recombinant antibody (TAB-0750CLV) is at -20°C or lower. For short-term storage, it can be kept at 2-8°C. To ensure stability, avoid repeated freeze-thaw cycles.

View the frequently asked questions answered by Creative Biolabs Support.

Citations

1. Sela, Mor, et al. "Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease." Advanced Materials 35.51 (2023): 2304654. https://doi.org/10.1002/adma.202304654
   This study explores the development and effectiveness of brain-targeted liposomes (BTL) loaded with monoclonal antibodies (mAbs) to reduce alpha-synuclein aggregation and improve behavioral symptoms in Parkinson's disease (PD). The researchers engineered liposomes conjugated with transferrin to enhance their delivery across the blood-brain barrier (BBB). These liposomes were loaded with the SynO4 antibody, which inhibits alpha-synuclein aggregation, a key pathological feature of PD. The study demonstrated that BTL effectively crossed the BBB, were taken up by neurons, and significantly reduced alpha-synuclein aggregation and neuroinflammation in mouse models of PD. Additionally, BTL treatment improved motor function and learning abilities in these models, showcasing the potential of this targeted delivery system for treating neurodegenerative diseases.
   Creative Biolabs contributed significantly to this research by providing the Anti-Human SNCA Therapeutic (SynO4) Antibody (Cat# TAB-0750CLV-L). This antibody was crucial for the experimental evaluation of the BTL's ability to reduce alpha-synuclein aggregation within neurons. By enabling the precise targeting and measurement of alpha-synuclein, the antibody from Creative Biolabs supported the validation of the therapeutic potential of BTL in mitigating the progression of Parkinson's disease.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-0750CLV, RRID: AB_3111792)

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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